Hormone Therapy or Hysterectomy for Endometrial Cancer: Balancing Fertility Preservation Against Survival

Fertility-preserving hormonal therapy is an increasingly accepted option among young women with early-stage endometrial cancer — but what are the long-term effects on survival? Researchers conducted a retrospective observational study of almost 16,000 women (age range, 18–49 years) with stage I, grade 1 or 2 endometrial cancer (stage I is limited to the uterus; grade 1 or 2 is associated with less-aggressive endometrioid histology). Approximately 1200 women received uterus-preserving progestin therapy and 14,700 underwent hysterectomy.