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Five years after the start of the Covid-19 pandemic, infections are becoming milder because of vaccination and infections that increase the population’s immunity. So, what was the impact of Covid-19 vaccination in the most recent season? To find out, U.S. Veterans Affairs investigators compared Covid-19–related outcomes between 164,000 people who received both the 2024–2025 Covid-19 and influenza vaccines and 132,000 people who received the influenza vaccine only. The population consisted mostly of older men (mean age, ≈72 years).
At 6 months, vaccine effectiveness was estimated at 29% against Covid-19–related emergency department visits, 39% against Covid-19–related hospitalizations, and 64% against Covid-19–related deaths…