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Patients often are reluctant to undergo colonoscopy for colorectal cancer (CRC) screening. For patients at average risk, stool-based tests are an alternative, but these tests currently aren’t recommended for patients at higher risk (e.g., those with personal history of polyps or family history of CRC). Researchers performed a systematic review to assess performance of fecal immunohistochemical testing (FIT) in higher-risk populations.
The 14 included studies had heterogeneous designs and used different diagnostic thresholds to define a “positive” FIT test, so variability in reported outcomes was considerable.
In patients with personal history of polyps or family history of CRC, the reported sensitivity of one-time FIT testin…