A Less-Invasive Approach to Mitral-Valve Replacement

Clinical Takeaway

: A novel transcatheter approach may provide an alternative to open heart surgery for patients with severe mitral regurgitation who are poor surgical candidates.

Context

Many patients with severe mitral regurgitation (MR) are poor candidates for surgical mitral-valve repair or replacement because of advanced age or comorbidities. Although transcatheter mitral edge-to-edge repair (M-TEER) is approved for these patients, many are poor candidates for M-TEER because of unfavorable valve anatomy. Several transcatheter repair systems have been developed for these patients. In a new manufacturer-funded, single-arm study, researchers studied one such system — the SAPIEN M3, which is delivered via the femoral vein and involves transseptal deployment of a nitinol ring around the mitral subvalvular apparatus to serve as a “dock” for implantation of a balloon-expandable valve.

The 300 participants all had moderat…

Reviewing Author

David J. Cohen, M.D., M.Sc.

Disclosures

Consultant/Advisory BoardMedtronic; Edwards Lifesciences; Abbott Vascular; Boston Scientific; St. Francis Hospital

Speaker’s BureauBoston Scientific; ZOLL Medical

Grant/Research SupportEdwards Lifesciences; Abbott Vascular; Boston Scientific; Corvia Medical; National Heart, Lung, and Blood Institute; Phillips, Inc.; St. Paul’s Hospital; V-Wave, Inc; ZOLL Medical; CathWorks, ANCORA

Editorial BoardsJACC; American Heart Journal; EuroIntervention; JSCAI; Structural Heart Journal

Leadership Positions in Professional SocietiesSociety of Thoracic Surgeons/American College of Cardiology TVT Registry (Co-Chair, Risk Model Development Committee); Cardiovascular Research Foundation (Co-Director, TCT Annual Meeting; Co-Director, New York Valves Annual Meeting)