Is Personalized Preeclampsia Prevention on the Horizon?

Early delivery can lower preeclampsia incidence among women with gestational hypertension, but limited evidence exists to individualize timing of delivery. In a U.K. trial of approximately 8000 women (mean age, 33; mean body-mass index, 29 kg/m²; 17% on aspirin) who were undergoing routine 36-week growth scans, investigators randomly assigned participants to usual care or an individualized, preeclampsia risk–based delivery-timing strategy. For the intervention, researchers used maternal characteristics, blood pressure, and serum biomarkers to estimate preeclampsia risk. Women with predicted risk ≥2% (≈20% of the intervention group) were offered scheduled delivery between 37 and 41 weeks based on their risk scores.