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Weaning patients from mechanical ventilation is typically accomplished through clinician-driven protocols managed by respiratory therapists, but can similar outcomes be achieved with automated closed-loop systems? These systems continuously analyze patient respiratory data and adjust ventilator settings accordingly without constant clinician input.
In a prior meta-analysis, closed-loop systems were shown to shorten the duration of mechanical ventilation and reduce complications during weaning, but most of the studies were small or conducted in ICUs with variable practices. Now, we have data from a large multicenter trial involving 1200 critically ill adults who were randomized within 1 hour of intubation to either closed-loop or proto…