Oropouche Fever Features to Note in Travelers to Latin America

Clinical Takeaway

: Symptoms of Oropouche fever can recur after initial resolution; prolonged Oropouche virus PCR positivity in urine suggests that it may be a useful sample for diagnosis.

Context

Oropouche fever is an arboviral infection transmitted by midges and mosquitoes that has been spreading in Latin America. Investigators, alerted to a cluster of cases, enrolled and followed for up to 3 months a cohort of 55 adults with polymerase chain reaction (PCR)-confirmed Oropouche virus infection, providing clinical and laboratory assessments. The patients were mostly women aged 20 to 40, and many lived near banana plantations or engaged in recreational activities near fresh water.

Key Results

The most common symptoms were fever, malaise, headache, myalgia, and retroorbital pain; rash, anorexia, and nausea also were common.
About one third of the participants had a recurrence of symptoms, at a median of 8 days after resolution.
Viru…

Reviewing Author

Anna Wald, M.D., M.P.H.

Disclosures

Consultant/Advisory BoardAicuris; Bayer; GSK; Innovative Molecules; Merck; MAPP Biopharmaceutical (Safety Monitoring Committee)

RoyaltiesUpToDate

Grant/Research SupportNIH/National Institute of Allergy and Infectious Diseases; GSK; Moderna; Assembly Biomedical; Aicuris

Editorial BoardsSexually Transmitted Diseases; Sexually Transmitted Infections; Journal of Infectious Diseases

Leadership PositionsID Division Chiefs Community of Practice (At-Large Member)