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Plasma phosphorylated tau 217 (p-tau217) is one of the most promising blood biomarkers for detecting Alzheimer’s disease–related amyloid pathology, with higher levels indicating a greater likelihood of pathology. However, circulating levels of this biomarker are influenced by biological factors unrelated to neurodegeneration, which may affect its diagnostic accuracy. To explore this further, researchers studied plasma p-tau217 levels relative to kidney function, body-mass index (BMI), and anemia among 2500 adults in South Korea.
Higher BMI was associated with lower plasma p-tau217 levels, which could increase the likelihood of false-negative interpretations, possibly related to plasma dilution or metabolic factors.
Reduced k…