Does Fecal Microbiota Therapy Reduce MDRO Gut Colonization?

Gut colonization with multidrug-resistant organisms (MDROs) is a known risk factor for subsequent MDRO infections, and attempts to address this risk with nonabsorbable oral antibiotics may promote resistance or cause only transient decolonization. Fecal microbiota therapy (FMT) — widely used for patients with recurrent Clostridioides difficile infection — may limit MDRO colonization by increasing both microbial diversity and colonization resistance. To test this hypothesis, investigators randomized 114 patients discharged from a specialized gastrointestinal disease unit with persistent MDRO colonization to receive either FMT delivered by colonoscopy or sham FMT. In most participants, MDRO colonization consisted of extended-spectrum β…