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Excessive crying in infancy is common, but an underlying medical cause is rarely identified during the first year (). To determine whether longer follow-up might uncover additional diagnoses, researchers retrospectively studied 530 colicky infants who were referred for evaluation before 5 months of age (median, 2 months). Most were born full term and fed formula.
10% of children were diagnosed with an organic condition that could potentially explain their crying.
The most common diagnosis — affecting 7% of all patients — was cow’s milk allergy confirmed by food challenge. (Reflux was not considered a potential cause due to inconclusive evidence linking it to colic.)
Other diagnoses included developmental delay, cerebr…