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Antiemetics are commonly used in the emergency department, but their effectiveness in this setting is unproven. Of the few trials that have been conducted, most lacked a placebo arm. In this randomized, placebo-controlled, double-blind trial, researchers compared droperidol (1.25 mg), prochlorperazine (10 mg), and metoclopramide (10 mg) in a convenience sample of 100 adult patients with moderate-to-severe nausea.
The main outcome measure was decrease in nausea at 30 minutes. Secondary outcomes included patient satisfaction, sedation, extrapyramidal side effects, and need for rescue therapy. Patients in the four groups received similar amounts of intravenous fluids overall (approximately 824 mL) but the amounts varied widely within groups. Th…