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The pathophysiology of migraine headache includes the release of vasoactive and inflammatory chemicals, resulting in vasodilatation and meningeal and vascular inflammation. Triptans and nonsteroidal anti-inflammatory drugs mitigate different parts of this cascade. Researchers assessed the efficacy of dual therapy in two manufacturer-funded, randomized, double-blind, parallel-group studies conducted in a total of 2956 patients at 118 U.S. clinical centers.
Patients aged 18 to 65 with at least a 6-month history of migraine headache and a monthly average of two to six moderate or severe episodes were randomized to one of four treatments to be taken after migraine onset: a single tablet containing either sumatriptan (85 mg) plus naproxen sodium …