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The CDC’s Sexually Transmitted Diseases Treatment Guidelines, 2006 recommend cephalosporins and fluoroquinolones for treatment of all patients with gonococcal infections except those who acquired the disease in California, Asia, or the Pacific Islands and men who have sex with men. During the past few years, resistance of Neisseria gonorrhoeae to fluoroquinolones has spread beyond these focused populations, and reports of resistance are now widespread. These changes in gonococcal resistance patterns led the CDC to issue an update to the guidelines.
All infections suspected to be due to gonorrhea must now be treated with cephalosporins (spectinomycin is recommended as an alternative agent, but it is not available in the U.S.). Uncomplicated g…