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Abciximab often is initiated immediately before percutaneous coronary intervention (PCI) and then continued for about 12 hours afterward. These authors hypothesized that initiating abciximab earlier and in combination with a lytic agent would improve outcomes. In a pharmaceutical company–sponsored, randomized, double-blind international study, 2452 patients older than 60 who had ST-segment-elevation myocardial infarction (STEMI; excluding localized inferior infarction) and who presented within 6 hours of symptom onset received one of three treatments: (1) half-dose reteplase plus abciximab started immediately after randomization (combination-facilitated PCI), (2) abciximab alone started immediately after randomization (abciximab-facilitated…