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Advising parents of children with fever is a daily occurrence in emergency departments. Researchers in England performed a randomized, blinded, controlled trial to compare ibuprofen (10 mg/kg every 6 to 8 hours), acetaminophen (15 mg/kg every 4 to 6 hours), and combination therapy for relieving fever and discomfort in 156 outpatients aged 6 months to 6 years with axillary temperatures of 37.8°C–41.0°C.
During the first 4 hours after administration of the first dose, ibuprofen plus acetaminophen was superior to acetaminophen alone for time without fever and similar to ibuprofen alone. During the first 24 hours, children who received combination therapy had 4.4 more hours without fever than those who received acetaminophen alone and 2.5 more h…