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Septic shock can induce severe microcirculatory alterations that manifest as reduced end-organ perfusion, reduced oxygen delivery, and increased accumulation of oxygen debt. In a prospective observational study, researchers evaluated whether improvements in early microcirculatory flow during resuscitation are associated with a reduced incidence of end-organ failure in septic patients.
Thirty-three adult patients who qualified for early goal-directed therapy were enrolled from a single institution’s emergency department or intensive care unit during 18 months. Sequential Organ Failure Assessment (SOFA) scores were calculated when resuscitation was started and 24 hours later. Microcirculatory flow was measured by sublingual videomicroscopy wit…