ED Visits for Antithrombotic Therapy-Induced Bleeding

Clopidogrel plus aspirin was associated with lower risk for emergency department visits for hemorrhage-related adverse drug events than warfarin.

Using data from a U.S. national adverse drug event (ADE) surveillance project and two national surveys of ambulatory medical care, researchers compared hemorrhage-related ADEs in patients taking clopidogrel and aspirin (dual antiplatelet therapy; DAT) with those in patients taking warfarin.

Minor hemorrhage involving epistaxis or skin accounted for most visits overall; visit rates for these events were similar for patients taking DAT and warfarin (59% and 54%). Gastrointestinal hemorrhage was the most common serious ADE in both groups (31% and 23%, respectively; not a significant difference), and the risk for hospital admission among this subset of patients was similar for both groups. Central nervous system hemorrhage occurred in 3.2% of pa…

Reviewing Author

J. Stephen Bohan, MD, MS, FACP, FACEP

Disclosures

RoyaltiesKlint Law Firm

Editorial boardsCritical Decisions in Emergency Medicine

J. Stephen Bohan, MD, MS, FACP, FACEP

Disclosures

RoyaltiesKlint Law Firm

Editorial boardsCritical Decisions in Emergency Medicine