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In a double-blind, randomized controlled trial, investigators compared total sedation time between a convenience sample of 67 children (age range, 2–17 years) who received ketamine-propofol and 69 who received ketamine alone for procedural sedation for reduction of an isolated extremity injury at a pediatric emergency department in Canada. The ketamine-propofol group received an intravenous bolus dose of 0.5 mg/kg ketamine and 0.5 mg/kg propofol, followed by 0.5 mg/kg propofol every 2 minutes as needed to achieve deep sedation. The ketamine-alone group received a bolus dose of 1.0 mg/kg ketamine, followed by 0.25 mg/kg ketamine every 2 minutes.
Median total sedation time (time from first drug injection to full recovery) was significantly sho…