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Is the ultrashort-acting sedative propofol an effective alternative to midazolam/ketamine for procedural sedation in adults? To find out, researchers in Israel randomized a convenience sample of 60 adult patients (age range, 18–65) who were undergoing orthopedic procedures to sedation with intravenous propofol (10-mg boluses every 10 seconds up to a maximum dose of 200 mg) or midazolam/ketamine (0.1 mg/kg of midazolam up to a maximum dose of 5 mg followed by 1 mg/kg of ketamine up to a maximum dose of 100 mg). Four patients in the midazolam/ketamine group and none in the propofol group received opioid analgesics (0.1 mg/kg of morphine 30 minutes before the procedure). All patients were preoxygenated via 100% nonrebreathing masks.
Average sed…