Rapid Rule-Out for AMI Is Getting More Rapid

An algorithm based on high-sensitivity cardiac troponin T accurately ruled out acute myocardial infarction in 60% of chest pain patients in 1 hour, but needs prospective validation.

To derive an algorithm for rapid rule-out of acute myocardial infarction (AMI) using high-sensitivity troponins, researchers analyzed data from a prospective, international, multicenter study of patients who presented within 12 hours of onset of acute chest pain suggestive of AMI. Patients on hemodialysis were excluded from the study, and those with ST-segment elevation MI were excluded from the current analysis.

Patients received standard care at their institution. Serum troponin was measured at presentation and at 1, 2, 3, and 6 hours using a high-sensitivity cardiac troponin-T (hs-cTnT) assay. Two independent cardiologists with access to all results adjudicated the final diagnosis. Among 872 patients with baseline and 1-hour hs-cTnT resul…

Reviewing Author

J. Stephen Bohan, MD, MS, FACP, FACEP

Disclosures

RoyaltiesKlint Law Firm

Editorial boardsCritical Decisions in Emergency Medicine

J. Stephen Bohan, MD, MS, FACP, FACEP

Disclosures

RoyaltiesKlint Law Firm

Editorial boardsCritical Decisions in Emergency Medicine