FDA Approves Injectable Ibuprofen

The FDA has approved the first injectable form of ibuprofen, Caldolor, to treat fever and pain in the hospital setting.

The agency cites a clinical trial in which Caldolor reduced the need for morphine among women who'd undergone abdominal hysterectomy.

Caution is warranted when using the drug in patients with heart failure, renal dysfunction, increased risk for thrombosis, or a history of ulcers or gastrointestinal bleeding. For such patients, the FDA says, low doses should be given for the shortest time possible.

In clinical trials, the most frequently reported adverse events included nausea, vomiting, and headache. High blood pressure and skin and allergic reactions have also been noted.