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Hyperglycemia is common in hospitalized patients and is associated with higher morbidity and mortality. However, intensive glycemic control can lead to hypoglycemia, which is also associated with poor outcomes. The American College of Physicians recently published guidelines that recommend against intensive insulin therapy for hospitalized patients, but none of the reviewed studies included non-intensive care unit (non-ICU) general medicine patients (JW Hosp Med Apr 4 2011).
To examine the effect of intensive glucose control in non-critically ill hospitalized patients, researchers reviewed 19 studies (9 randomized and 10 observational) that compared intensive glycemic control with less aggressive control in patients hospitalized in non-ICU s…