Loading...
Previous reports indicate that fluconazole prophylaxis can dramatically decrease the incidence of candida bloodstream infections among hematopoietic stem-cell transplant recipients, but also changes the relative proportions of candida isolates to favor organisms more resistant to fluconazole, such as Candida glabrata. Researchers from the NIH and the Fred Hutchinson Cancer Research Center recently examined fluconazole-resistance mechanisms in C. glabrata isolates from such transplant recipients. They studied all blood culture results from patients with more than one weekly culture revealing C. glabrata between July 1995 and July 1997 (104 isolates, 29 patients).
Karyotyping of sequential C. glabrata isolates showed that in all but one patien…