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Despite receiving high-dose intravenous immune globulin (IVIG) within the first 10 days of illness, approximately 5% of children with Kawasaki disease (KD) develop coronary aneurysms. Previous studies, all with design limitations, have suggested that steroids as an adjunct to IVIG may improve the prognosis (see Journal Watch Infectious Diseases Nov 8 2006). Now, researchers have conducted a multicenter, randomized, double-blind, placebo-controlled trial to shed light on this issue. In this trial, 199 children with KD and fever duration ≤10 days received IVIG 2 g/kg with aspirin. (Nonresponding patients with prolonged fever were given additional doses of IVIG.) In addition, half received a single pulse of methylprednisolone (MP) 30 mg/kg, an…