Do PPIs Increase Risk for CAP?

In a large population-based case-control study, the use of proton-pump inhibitors was associated with increased risk for community-acquired pneumonia.

Proton-pump inhibitors (PPIs) have been associated with increased risk for gastrointestinal infections such as salmonellosis and Clostridium difficile colitis. In addition, one study (Journal Watch Infectious Diseases Nov 22 2004) has shown PPI use to be associated with community-acquired pneumonia (CAP). Now, investigators have conducted a large population-based case-control study to evaluate the relation between PPI use and CAP.

Through use of patient registries, the researchers obtained data on 7642 individuals hospitalized with CAP in the county of Funen, Denmark, at any time from 2001 through 2004. These case patients were matched by sex and age with 34,176 controls drawn from the same population. PPI and other drug exposures were obtai…

Reviewing Author

Daniel J. Diekema, MD, MS

Do PPIs Increase Risk for CAP?

Topics

Reviewing Author