Do Inhaled Corticosteroids Increase Pneumonia Risk in COPD?

A population-based study showed a 70% increase in pneumonia hospitalizations among patients with COPD who were using inhaled corticosteroids.

Chronic obstructive pulmonary disease (COPD) is characterized by progressive airflow impairment and lung inflammation. Inhaled corticosteroids (ICs) are prescribed for up to 50% of patients with COPD, although no beneficial effect has been demonstrated. ICs have fewer side effects than oral corticosteroids, but they can cause systemic effects. One study showed a >60% increase in pneumonia risk among patients with COPD who were treated with ICs.

To examine this possible effect further, investigators conducted a population-based cohort study with a nested case-control analysis. Using data from the health registry of Quebec, Canada, they identified 175,906 patients with COPD (mean age, 72). Within this group, current IC use was associated with …

Reviewing Author

Neil M. Ampel, MD

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Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesCoccidioidomycosis Study Group (Past President, Secretary, Treasurer)

Neil M. Ampel, MD

Disclosures

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesCoccidioidomycosis Study Group (Past President, Secretary, Treasurer)

Do Inhaled Corticosteroids Increase Pneumonia Risk in COPD?

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Reviewing Author