Factors Associated with Invasive Pneumococcal Infection in Adults

In a large, observational study, mortality and disease severity were associated with older age, immunosuppression, and underlying chronic disease but not with pneumococcal serotype.

The incidence, severity, and mortality of invasive pneumococcal disease (IPD) are determined by numerous host- and organism-related factors. Vaccination of children with the conjugate pneumococcal vaccine has reduced the incidence of IPD associated with vaccine serotypes in adults. What roles do pneumococcal serotype and host factors play in determining mortality and severity of IPD?

To find out, researchers analyzed data from 796 patients enrolled in a prospective, multinational, observational study of pneumococcal bacteremia. Pneumococcal serotypes were divided into three groups: “invasive” (types 1, 5, and 7); “pediatric” (6, 9, 14, 19, and 23); and “conjugate vaccine” (4, 6B, 9V, 14, 18C, 19F, and 23F). Illness severity was assessed usin…

Reviewing Author

Neil M. Ampel, MD

Disclosures

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesCoccidioidomycosis Study Group (Past President, Secretary, Treasurer)

Neil M. Ampel, MD

Disclosures

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesCoccidioidomycosis Study Group (Past President, Secretary, Treasurer)

Factors Associated with Invasive Pneumococcal Infection in Adults

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Reviewing Author