Pregnancy and HIV Disease Progression

In a cohort study conducted since the introduction of potent combination ART, pregnancy seemed to reduce a woman’s risk for HIV disease progression.

Now that antiretroviral therapy (ART) can prevent most mother-to-child HIV transmission, more HIV-infected women are considering having children. However, most studies of pregnancy’s effect on HIV disease progression were performed before the current treatment era. Now, investigators have examined this association in a large cohort of HIV-infected women who received care at a Nashville, Tennessee, clinic between 1997 and 2004. Multivariate Cox proportional hazards models were used to determine variables associated with disease progression (defined as any new AIDS-defining event or death). A matched-pair analysis was also performed, wherein 81 HIV-infected pregnant women were matched 1:1 with nonpregnant HIV-infected women according to age, …

Reviewing Author

Daniel J. Diekema, MD, MS

Pregnancy and HIV Disease Progression

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Reviewing Author