Emergence and Spread of Community-Associated MRSA

Comparative whole-genome sequencing of USA300 MRSA isolates indicates recent clonal expansion.

The emergence of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) — particularly of strains in the USA300 group — has been sudden and dramatic. The origin of the USA300 strains, and the extent of their genetic diversity, are unclear. To address these issues, researchers performed comparative whole-genome sequencing and virulence testing on 11 clinical USA300 isolates obtained between 2002 and 2005 in eight widespread states. The genome of one of the isolates had recently been sequenced by conventional methods; this strain was chosen as the reference strain against which the isolates were compared.

Eight of the USA300 strains were highly related to the reference strain, with only a minimal number of genetic differenc…

Reviewing Author

Richard T. Ellison III, MD

Disclosures

Consult/Advisory BoardAcurx Pharmaceuticals, LLC;

Grant/Research SupportDoctors Company Foundation, Massachusetts Department of Public Health

Richard T. Ellison III, MD

Disclosures

Consult/Advisory BoardAcurx Pharmaceuticals, LLC;

Grant/Research SupportDoctors Company Foundation, Massachusetts Department of Public Health