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Who wants to get a shot? Detailed epidemiologic analyses are not needed to determine that fear of injections is a limiting factor in vaccine acceptance and that use of alternative delivery systems could greatly improve immunization rates. A multinational team of researchers recently used a mouse model to investigate the immunogenicity of sublingually administered influenza virus.
Mice were immunized sublingually twice, 2 weeks apart, with formalin-inactivated influenza virus (A/PR/8; H1N1) either alone or together with a mucosal adjuvant. Both preparations, compared with a saline control vaccine, induced significant levels of systemic IgG and mucosal secretory IgA (SIgA); the preparation with adjuvant was also associated with increases in in…