Candida Infective Endocarditis

Candida infective endocarditis was associated with high morbidity and mortality; outcomes were better with combination or sequential antifungal therapy.

Candida infective endocarditis (IE) is rare but often fatal. To increase understanding of this condition, researchers (with partial industry support) examined records from a database of IE cases registered from 61 centers in 28 countries.

Among 2749 cases of definite IE between June 2000 and August 2005, 33 (1.2%) were attributable to Candida infection. Forty-eight percent of these cases were caused by C. albicans, 21% by C. parapsilosis, 15% by C. glabrata, 9% by C. tropicalis, and 6% by unidentified species. Treatment data were available for 27 patients, of whom 59% received conventional or lipid amphotericin B, 44% received fluconazole, and 37% received caspofungin or voriconazole.

Compared to patients with nonfungal IE, those with Candid…

Reviewing Author

Thomas Glück, MD

Disclosures

Editorial BoardsConsilium Infectiorum by InfectoPharm, Infection

Thomas Glück, MD

Disclosures

Editorial BoardsConsilium Infectiorum by InfectoPharm, Infection