PPIs and CAP Risk

Although short-term use of proton-pump inhibitors was associated with increased risk for community-acquired pneumonia, long-term use was not.

Several studies have suggested that taking gastric acid–suppressing drugs, such as proton-pump inhibitors (PPIs) or histamine-2–receptor antagonists, increases the risk for community-acquired pneumonia (CAP), presumably by providing an acid-poor upper gastrointestinal milieu that allows for bacterial overgrowth (JW Infect Dis May 23 2007). Using General Practice Research Database records for May 1987 through April 2002, researchers in the U.K. (all of whom consult for or have grants from PPI manufacturers) performed a nested case-control study to examine the possible association between PPIs and CAP risk. Case patients — 80,066 adults who had received a diagnosis of CAP — were compared with 799,881 control patients who were matched by pract…

Reviewing Author

Stephen G. Baum, MD

Disclosures

Consultant/Advisory BoardClinical Infectious Diseases

RoyaltiesUpToDate

Editorial BoardsMedical Letter

Stephen G. Baum, MD

Disclosures

Consultant/Advisory BoardClinical Infectious Diseases

RoyaltiesUpToDate

Editorial BoardsMedical Letter

PPIs and CAP Risk

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Reviewing Author