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Recent studies have suggested that vancomycin treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections may fail more frequently when MICs are on the high side (1.5 or 2 µg/mL) of the Clinical and Laboratory Standards Institute (CLSI) susceptible category than when they are lower. Now, using 101 MRSA bacteremia isolates from 2002 to 2006, researchers in Texas have examined whether vancomycin susceptibility results might vary depending on the test method used.
Vancomycin MICs for each isolate were assessed by CLSI broth dilution, CLSI agar dilution, and the Etest using two different brands of Mueller-Hinton agar plates. All tests for each isolate were performed at the same time from the same inoculum suspension.
The modal MIC …