Therapeutic Monitoring of Vancomycin in Adults

Target Population: Clinicians who treat adult patients with intravenous vancomycin; pharmacists

Type: Consensus review using the Canadian Medical Association’s evidence-grading system

Key Points: Trough serum vancomycin concentration, obtained at steady state just before the next dose, is the optimal monitoring parameter. The target trough concentration is >10 mg/L for organisms with an MIC <1 and >15 mg/L for those with an MIC of 1; among patients with normal renal function, optimal area-under-the-curve/MIC targets for organisms with MICs ≥2 are not achievable with conventi…