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Although we have strong evidence that male circumcision reduces the incidence of HIV infection in high-risk men, its benefits regarding other sexually transmitted infections (STIs) have remained unclear. To examine this wider issue, researchers examined data obtained in Uganda during two earlier trials of male circumcision for preventing HIV infection. A total of 5534 uncircumcised males aged 15 to 49 were involved.
Of 3393 participants who were HIV and herpes simplex virus type 2 (HSV-2) seronegative at enrollment, 1684 were randomized to undergo immediate circumcision (intervention group) and 1709 to undergo circumcision 24 months later (control group). Serial screening (physical examination, an interview, and testing for HSV-2 and HIV inf…