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Triple-reassortant swine influenza A (H1) viruses, which contain gene segments from avian, human, and swine influenza viruses, have been found in North American swine since the late 1990s. In a new report, investigators characterize the clinical and epidemiologic features of 11 sporadic cases of human infection with triple-reassortant viruses, detected through routine surveillance systems in the U.S., from December 2005 through February 2009. Human infections caused by novel influenza A viruses (including those that are nonhuman in origin) became nationally notifiable diseases in June 2007.
The patients were aged 16 months to 48 years (median, 10 years); 7 of the 11 were male. All lived in the Midwest or the South, and nine reported proximit…