Cutaneous Non–AIDS-Defining Cancers in HIV-Infected Individuals

Much less is known about cutaneous non–AIDS-defining cancers (NADCs) in HIV-infected individuals than about Kaposi sarcoma (KS). In particular, the effect of immune status and antiretroviral therapy (ART) on cutaneous neoplasms other than KS remains undefined. To shed light on this issue, investigators examined data collected for 1986 through 2006 as part of the U.S. Military HIV Natural History Study (4490 HIV-infected participants; 33,760 person-years of follow-up).

Cutaneous malignancies developed in 254 participants (5.7%) during the study period. KS incidence peaked in 1991–1995, then declined significantly after the introduction of combination ART. The incidence of cutaneous NADCs remained much the same throughout the study period; in …