Immune Response to Sporozoite Inoculation by Mosquitoes

Volunteers exposed to malaria-infected mosquitoes under chloroquine cover did not become parasitemic after later challenge.

Many gaps remain in our understanding of protective antimalarial immunity. In a proof-of-concept study conducted in the Netherlands, 15 healthy volunteers from nonmalarious areas were exposed to mosquito bites while receiving weekly doses of chloroquine. Those in the vaccine group (n=10) were exposed three times, at monthly intervals, to bites of 12 to 15 mosquitoes infected with a chloroquine-sensitive strain of Plasmodium falciparum. Infection in engorged mosquitoes was confirmed by the presence of sporozoites at dissection. Five control volunteers were exposed at the same intervals to laboratory-reared uninfected mosquitoes. Four weeks after stopping chloroquine prophylaxis (8 weeks after the last mosquito bites), all 15 volunteers were …

Reviewing Author

Mary E. Wilson, MD

Disclosures

Consultant/Advisory BoardOneHealthTrust (formerly Center for Disease Dynamics, Economics, and Policy); Global Health Institute, University of Wisconsin

RoyaltiesUpToDate

Editorial BoardsJournal of Travel Medicine

Mary E. Wilson, MD

Disclosures

Consultant/Advisory BoardOneHealthTrust (formerly Center for Disease Dynamics, Economics, and Policy); Global Health Institute, University of Wisconsin

RoyaltiesUpToDate

Editorial BoardsJournal of Travel Medicine