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Coxsackievirus B3 (CVB3) is a common cause of infectious myocarditis, and CVB load, replication, and persistence are directly related to cardiac injury and disease progression. A soluble coxsackievirus-adenovirus receptor (sCAR) binds to these viruses and leads to irreversible loss of infectivity. Dimeric sCAR fused with the Fc immunoglobulin region has a prolonged half-life and does not induce side effects. In the present study, investigators created an in vivo delivery system by inserting the gene for sCAR-Fc into an adenovirus (AdG12) containing a transactivator that allows sCAR-Fc transcription only in the presence of doxycycline.
Mice were intravenously injected with AdG12 and then infected with CVB3 2 days later. Doxycycline was provid…