A Single H1N1 Immunization for Children?

A randomized clinical trial showed that a single 15-µg dose was immunogenic for children aged 6 months or older.

Given the substantial morbidity and mortality of 2009 H1N1 influenza in children, the best vaccination strategy for this group is a major question. Because studies of seasonal influenza vaccines have shown that two doses are required to provide optimal protection for children aged ≤9 years, the CDC has recommended that this population receive two doses of the monovalent 2009 H1N1 vaccine. Now, data from a manufacturer-sponsored, multicenter, controlled trial suggest that a single dose of H1N1 vaccine is adequate for most young children.

Investigators in Australia randomized 370 children aged 6 months to <9 years to receive two intramuscular injections of an unadjuvanted, inactivated 2009 H1N1 vaccine (hemagglutinin antigen content, 15 or 30 …

Reviewing Author

Richard T. Ellison III, MD

Disclosures

Consult/Advisory BoardAcurx Pharmaceuticals, LLC;

Grant/Research SupportDoctors Company Foundation, Massachusetts Department of Public Health

Richard T. Ellison III, MD

Disclosures

Consult/Advisory BoardAcurx Pharmaceuticals, LLC;

Grant/Research SupportDoctors Company Foundation, Massachusetts Department of Public Health

A Single H1N1 Immunization for Children?

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Reviewing Author