Long-Term Antibiotic Therapy for Bone and Joint Infections

Two oral combination regimens — rifampicin/linezolid and rifampicin/trimethoprim sulfamethoxazole — performed equally well.

Bone and joint infections are difficult to eradicate, especially in the presence of a prosthetic device, and require prolonged antibiotic therapy. Critical issues in the treatment of such infections are adequate tissue penetration of the antibiotic agent — or agents — chosen, development of resistance, and toxicity. Rifampicin has excellent activity against staphylococci (the pathogens most commonly responsible for bone and joint infections) and good tissue penetration. However, because resistance to this drug develops rapidly during monotherapy, rifampicin should be used only together with other antibiotics.

To find out which rifampicin combinations are efficacious and well tolerated during prolonged therapy, researchers in France conducted…

Reviewing Author

Thomas Glück, MD

Disclosures

Editorial BoardsConsilium Infectiorum by InfectoPharm, Infection

Thomas Glück, MD

Disclosures

Editorial BoardsConsilium Infectiorum by InfectoPharm, Infection