Dengue Virus Infections in Infants

In a dengue-endemic area, the incidence of dengue infection exceeded 10% in infants aged 2–15 months; illness was generally mild or asymptomatic.

Infants may be at increased risk for severe dengue virus (DENV) infection because of the presence of maternal DENV antibodies, which can be associated with antibody-dependent enhancement of viral replication. Investigators recently conducted a prospective study in a semiurban community in the Philippines to examine DENV infections during infancy.

Healthy infants aged 6 to 18 weeks were enrolled and followed for acute febrile illnesses. Among 4441 infants, 353 had acute undifferentiated febrile illnesses between January 2007 and January 2008. Eleven percent of these illnesses were caused by DENV, as determined by serotype-specific reverse-transcriptase polymerase chain reaction in acute-phase sera and DENV IgM/IgG enzyme-linked immunosorbent …

Reviewing Author

Mary E. Wilson, MD

Disclosures

Consultant/Advisory BoardOneHealthTrust (formerly Center for Disease Dynamics, Economics, and Policy); Global Health Institute, University of Wisconsin

RoyaltiesUpToDate

Editorial BoardsJournal of Travel Medicine

Mary E. Wilson, MD

Disclosures

Consultant/Advisory BoardOneHealthTrust (formerly Center for Disease Dynamics, Economics, and Policy); Global Health Institute, University of Wisconsin

RoyaltiesUpToDate

Editorial BoardsJournal of Travel Medicine

Dengue Virus Infections in Infants

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Reviewing Author