Does Pneumococcal Vaccination Protect Against Cardiovascular Events?

In a prospective cohort study involving nearly 85,000 men, vaccination did not reduce risk for myocardial infarction or stroke.

We have strong evidence showing that acute coronary events can be precipitated by infections and that influenza vaccination reduces the risk for myocardial infarction (MI) and stroke. One recent trial has suggested that pneumococcal vaccination provides similar protection against cardiovascular events (CMAJ 2008; 179:773). To further explore this possibility, researchers analyzed prospectively collected data from the California Men's Health Study (84,170 men aged 45–69 in January 2000).

From 2000 through 2007, 36,309 study participants received at least one dose of the pneumococcal vaccine; a total of 2705 first MIs and 1134 strokes were identified. In a multivariate analysis adjusted for confounders including smoking, diabetes, hypertension…

Reviewing Author

Richard T. Ellison III, MD

Disclosures

Consult/Advisory BoardAcurx Pharmaceuticals, LLC;

Grant/Research SupportDoctors Company Foundation, Massachusetts Department of Public Health

Richard T. Ellison III, MD

Disclosures

Consult/Advisory BoardAcurx Pharmaceuticals, LLC;

Grant/Research SupportDoctors Company Foundation, Massachusetts Department of Public Health

Does Pneumococcal Vaccination Protect Against Cardiovascular Events?

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Reviewing Author