Multidrug-Resistant E. coli

A single Escherichia coli lineage was estimated to account for 69% of isolates with extended-cephalosporin resistance and 67% of those with fluoroquinolone resistance.

One lineage of Escherichia coli, ST131, has been associated with resistance to β-lactams (through production of extended-spectrum β-lactamases [ESBLs], especially CTX-M-15) and to fluoroquinolones. This lineage has been increasingly prevalent in many regions worldwide. To determine whether it is a major contributor to the current rise in antibiotic-resistant E. coli infections in the U.S., researchers examined isolates collected from hospitalized patients in 2007 as part of two antimicrobial-surveillance programs.

Among 1596 E. coli isolates from 33 widely distributed U.S. medical centers, 118 (7%) were found to have reduced susceptibility to extended-spectrum cephalosporins and were considered ESBL positive. The 34 ESBL-positive isolates th…

Reviewing Author

Neil M. Ampel, MD

Disclosures

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesCoccidioidomycosis Study Group (Past President, Secretary, Treasurer)

Neil M. Ampel, MD

Disclosures

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesCoccidioidomycosis Study Group (Past President, Secretary, Treasurer)