Parapoxvirus Infection in Hunters: Bambi's Revenge

A novel parapoxvirus was identified in nodular skin lesions on the fingers of two hunters who had field-dressed deer.

Parapoxvirus infections in ruminants (e.g., orf virus infections in sheep and goats; pseudocowpox virus infections in cattle) are seen worldwide. Humans can acquire these viruses by direct contact with infected animals.

In 2009, parapoxvirus infections were suspected in two hunters in the U.S. who developed index-finger nodules after field-dressing white-tailed deer. Tissue specimens from these patients were sent to the CDC, where they were subjected to sophisticated laboratory analyses.

Ovoid virions consistent with parapoxvirus were seen with electron microscopy. Immunohistochemical staining revealed intracellular viral antigens along the superficial stratum spinosum. Polymerase chain reaction assays confirmed the presence of parapoxvirus i…

Reviewing Author

Larry M. Baddour, MD

Disclosures

RoyaltiesUpToDate, Inc. (Authorship duties)

Larry M. Baddour, MD

Disclosures

RoyaltiesUpToDate, Inc. (Authorship duties)