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Approximately 6 to 12 million head lice infestations occur in the U.S. each year, most of them among young children. Although various remedies are available, the American Academy of Pediatrics currently recommends topical 11800d44ermethrin as the first-line treatment. Spinosad (Natroba), which received FDA approval on January 18, 2011, for use in patients aged ≥4 years, now provides an additional option.
Spinosad has a unique mechanism of action, causing paralysis and death of lice. Like permethrin, this product is a nonprescription topical agent. It is applied to dry hair/scalp, left on for 10 minutes, and then rinsed.
FDA approval was based on two manufacturer-sponsored, phase III, multicenter, randomized trials in which spinosad without ni…