Broad-Spectrum Cephalosporin Resistance and Outcomes in Intra-Abdominal Infection

According to a study conducted in South Korea, empirical antibiotic regimens for intra-abdominal infections need not include coverage for pathogens resistant to broad-spectrum cephalosporins.

The proportion of gram-negative pathogens with resistance to broad-spectrum cephalosporins — a surrogate marker for extended-spectrum β-lactamase production — is rapidly increasing. Previous reports have indicated that such resistance worsens outcomes in patients with bacteremia, but is this also true for patients with intra-abdominal infections?

To find out, researchers in South Korea conducted a retrospective, multicenter study involving patients who were treated for bacteremic gram-negative intra-abdominal infections between 2006 and 2009 (n=365).

Biliary tract infection was the most common source of bacteremia (56%), followed by peritonitis (17%) and intra-abdominal abscess (15%). The pathogens isolated from blood cultures were Escherichi…

Reviewing Author

Thomas Glück, MD

Disclosures

Editorial BoardsConsilium Infectiorum by InfectoPharm, Infection

Thomas Glück, MD

Disclosures

Editorial BoardsConsilium Infectiorum by InfectoPharm, Infection