Concomitant Antibiotics Reduce the Cure Rates for C. difficile Infection

The effect was greater in patients taking vancomycin for CDI than in those taking fidaxomicin.

Clostridium difficile infection (CDI) results from disruption of normal gut flora and overgrowth of C. difficile in the bowel. Management, in part, involves discontinuation of any antibiotics a patient has been using. However, some patients with CDI also have other infections that necessitate the use of concomitant systemic antibiotics. In a study funded by the manufacturers of fidaxomicin, researchers assessed the effects of concomitant antibiotics on outcomes.

The researchers analyzed data pooled from two prospective, double-blind, randomized trials in which adults with CDI took oral fidaxomicin or oral vancomycin for 10 days. Among the 999 participants who were evaluable for cure, 275 received concomitant antibiotics during treatment, fo…

Reviewing Author

Neil M. Ampel, MD

Disclosures

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesCoccidioidomycosis Study Group (Past President, Secretary, Treasurer)

Neil M. Ampel, MD

Disclosures

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesCoccidioidomycosis Study Group (Past President, Secretary, Treasurer)