An Ultrashort Regimen for Latent TB Looks Promising — in Mice

In a mouse model of latent tuberculosis, 1 month of the diarylquinoline TMC207 alone was superior to isoniazid alone in reducing the lung burden of Mycobacterium tuberculosis.

Ultrashort regimens for treating latent tuberculosis infection (LTBI) caused by susceptible strains of Mycobacterium tuberculosis would be very helpful. To facilitate research in this area, investigators developed a murine model of LTBI in which mice are vaccinated with a strain of bacillus Calmette-Guérin, followed 6 weeks later by an aerosol challenge with M. tuberculosis. Six weeks after this, the mice have approximately 100,000 (4 log₁₀) colony-forming units (CFUs) of M. tuberculosis per lung — a level that is maintained over the next 7 months. In a previous study using this model, the investigators demonstrated that rifapentine was more effective at preventing relapse of TB than isoniazid plus rifampin (JW Infect Dis Dec 23 2009).

Now, …

Reviewing Author

Neil M. Ampel, MD

Disclosures

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesCoccidioidomycosis Study Group (Past President, Secretary, Treasurer)

Neil M. Ampel, MD

Disclosures

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesCoccidioidomycosis Study Group (Past President, Secretary, Treasurer)

An Ultrashort Regimen for Latent TB Looks Promising — in Mice

Topics

Reviewing Author