H1N1 Influenza Vaccination During Pregnancy Is Protective and Safe

One dose of the 2009 pandemic H1N1 vaccine given during the second or third trimester induced seroprotection in the women and their newborns.

Pregnant women and infants who contract influenza are at particular risk for severe illness. Vaccination of infants aged <6 months is not recommended; however, previous studies have shown that seasonal influenza vaccine given during pregnancy is protective to both the mothers and their babies. Now, in a phase II, prospective clinical trial, investigators in France have examined whether an influenza A (H1N1) vaccine might be similarly protective.

In this partially industry-funded study, 107 pregnant women (58 in their second trimester, 49 in their third) received a single injection of nonadjuvanted, monovalent 2009 influenza A (H1N1) vaccine containing 15 µg of hemagglutinin. Influenza antibody titers were measured in maternal blood samples c…

Reviewing Author

Stephen G. Baum, MD

Disclosures

Consultant/Advisory BoardClinical Infectious Diseases

RoyaltiesUpToDate

Editorial BoardsMedical Letter

Stephen G. Baum, MD

Disclosures

Consultant/Advisory BoardClinical Infectious Diseases

RoyaltiesUpToDate

Editorial BoardsMedical Letter

H1N1 Influenza Vaccination During Pregnancy Is Protective and Safe

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Reviewing Author